Radiosynthesis of the α4β2 nicotinic acetylcholine receptor ligand: 5‐((1‐[ 11 C]‐methyl‐2‐( S )‐pyrrolidinyl)methoxy)‐2‐chloro‐3‐(( E )‐2‐(2‐fluoropyridin‐4‐yl)vinyl)pyridine | Zendy

Ravert Hayden T. | Zendy; Zhang Yi | Zendy; Horti Andrew | Zendy; Dannals Robert F. | Zendy

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Radiosynthesis of the α4β2 nicotinic acetylcholine receptor ligand: 5‐((1‐[ 11 C]‐methyl‐2‐( S )‐pyrrolidinyl)methoxy)‐2‐chloro‐3‐(( E )‐2‐(2‐fluoropyridin‐4‐yl)vinyl)pyridine

Author(s) -

Ravert Hayden T.,

Zhang Yi,

Horti Andrew,

Dannals Robert F.

Publication year - 2006

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1064

Subject(s) - chemistry , radiosynthesis , pyridine , yield (engineering) , methyl iodide , nicotinic agonist , ligand (biochemistry) , acetylcholine receptor , nicotinic acetylcholine receptor , iodide , medicinal chemistry , chemical synthesis , nuclear chemistry , radiochemistry , receptor , organic chemistry , in vitro , biochemistry , nuclear medicine , positron emission tomography , materials science , metallurgy , medicine

5‐((1‐[ 11 C]‐methyl‐2‐( S )‐pyrrolidinyl)methoxy)‐2‐chloro‐3‐(( E )‐2‐(2‐fluoropyridin‐4‐yl)‐vinyl)pyridine ([ 11 C]‐FPVC) was synthesized from [ 11 C]‐methyl iodide and the corresponding normethyl precursor. The average time of synthesis, purification, and formulation was 42 min with an average non‐decay‐corrected radiochemical yield of 19%. The average specific radioactivity was 359 GBq/µmol (9691 mCi/µmole) at end of synthesis (EOS). Copyright © 2006 John Wiley & Sons, Ltd.

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