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Radiosynthesis of the α4β2 nicotinic acetylcholine receptor ligand: 5‐((1‐[ 11 C]‐methyl‐2‐( S )‐pyrrolidinyl)methoxy)‐2‐chloro‐3‐(( E )‐2‐(2‐fluoropyridin‐4‐yl)vinyl)pyridine
Author(s) -
Ravert Hayden T.,
Zhang Yi,
Horti Andrew,
Dannals Robert F.
Publication year - 2006
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1064
Subject(s) - chemistry , radiosynthesis , pyridine , yield (engineering) , methyl iodide , nicotinic agonist , ligand (biochemistry) , acetylcholine receptor , nicotinic acetylcholine receptor , iodide , medicinal chemistry , chemical synthesis , nuclear chemistry , radiochemistry , receptor , organic chemistry , in vitro , biochemistry , nuclear medicine , positron emission tomography , materials science , metallurgy , medicine
5‐((1‐[ 11 C]‐methyl‐2‐( S )‐pyrrolidinyl)methoxy)‐2‐chloro‐3‐(( E )‐2‐(2‐fluoropyridin‐4‐yl)‐vinyl)pyridine ([ 11 C]‐FPVC) was synthesized from [ 11 C]‐methyl iodide and the corresponding normethyl precursor. The average time of synthesis, purification, and formulation was 42 min with an average non‐decay‐corrected radiochemical yield of 19%. The average specific radioactivity was 359 GBq/µmol (9691 mCi/µmole) at end of synthesis (EOS). Copyright © 2006 John Wiley & Sons, Ltd.