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Synthesis of deuterated dihydrochalcones
Author(s) -
Comeskey Daniel J.,
Cooney Janine M.,
Rowan Daryl D.
Publication year - 2006
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1057
Subject(s) - chemistry , phloretin , naringin , deuterium , naringenin , glycoside , organic chemistry , chromatography , flavonoid , physics , quantum mechanics , antioxidant
The dihydrochalcones phloretin and phloridzin are major phenolic constituents of apple fruit. Phloretin‐ d 4 , deuterated at both the α and β positions, was prepared by hydrogenolysis of naringenin and by deuterium exchange from unlabelled phloretin using Pd/C and sodium formate with methanol‐ d 1 as the source of deuterium. Deuterated derivatives of the glycosides, phloridzin and naringin dihydrochalcone, were similarly prepared. Copyright © 2006 John Wiley & Sons, Ltd.
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