Premium
Synthesis of d 3 ‐cerivastatin for use as internal standard in a LC/MS/MS method developed for quantitation of the drug in human serum
Author(s) -
Chen BangChi,
Bednarz Mark S.,
Zhang Huiping,
Guo Peng,
Jemal Mohammed,
Robl Jeffrey A.,
Biller Scott A.,
Sundeen Joseph E.,
Balasubramanian Balu,
Barrish Joel C.
Publication year - 2006
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1050
Subject(s) - cerivastatin , chemistry , chromatography , drug , human plasma , combinatorial chemistry , pharmacology , biochemistry , enzyme , medicine , reductase
d 3 ‐Cerivastatin was synthesized as an internal standard for use in a LC/MS/MS method developed for the simultaneous quantitative determination of the drug in human serum. d 3 ‐Cerivastatin was efficiently prepared on large scale from d 3 ‐iodomethane using improved procedures. Copyright © 2006 John Wiley & Sons, Ltd.