A novel asymmetric synthesis of tritium and carbon‐14 labeled ( R )‐ibuprofen | Zendy

Zhang Yinsheng | Zendy; Hong Yang | Zendy; Huang Che C. | Zendy; Belmont Daniel | Zendy

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A novel asymmetric synthesis of tritium and carbon‐14 labeled ( R )‐ibuprofen

Author(s) -

Zhang Yinsheng,

Hong Yang,

Huang Che C.,

Belmont Daniel

Publication year - 2006

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1040

Subject(s) - chemistry , tritium , yield (engineering) , ibuprofen , carbon 14 , radiochemistry , carbon fibers , tritium illumination , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , nuclear chemistry , pharmacology , nuclear physics , medicine , materials science , physics , composite material , composite number , metallurgy

An efficient asymmetric synthesis of tritium and carbon‐14 labeled R ‐ibuprofen was achieved in good overall yield (15% and 47%, respectively) and excellent enantiomerical excess (>98% e.e.), using (4 R , 5S)‐4‐methyl‐5‐phenyl‐2‐oxazolidinone as a chiral auxiliary. Copyright © 2006 John Wiley & Sons, Ltd.

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