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A novel asymmetric synthesis of tritium and carbon‐14 labeled ( R )‐ibuprofen
Author(s) -
Zhang Yinsheng,
Hong Yang,
Huang Che C.,
Belmont Daniel
Publication year - 2006
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1040
Subject(s) - chemistry , tritium , yield (engineering) , ibuprofen , carbon 14 , radiochemistry , carbon fibers , tritium illumination , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , nuclear chemistry , pharmacology , nuclear physics , medicine , materials science , physics , composite material , composite number , metallurgy
Abstract An efficient asymmetric synthesis of tritium and carbon‐14 labeled R ‐ibuprofen was achieved in good overall yield (15% and 47%, respectively) and excellent enantiomerical excess (>98% e.e.), using (4 R , 5S)‐4‐methyl‐5‐phenyl‐2‐oxazolidinone as a chiral auxiliary. Copyright © 2006 John Wiley & Sons, Ltd.