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Synthesis of [ 13 C 4 , 15 N 2 ]pyrrolo[2,1‐ f ][1,2,4]triazinone
Author(s) -
Ogan Marc D.,
Tran Scott Bach,
Rinehart J. Kent
Publication year - 2006
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1030
Subject(s) - chemistry , ethyl acetoacetate , yield (engineering) , ammonium hydroxide , organic chemistry , catalysis , materials science , metallurgy
[ 13 C 4 , 15 N 2 ]Pyrrolotriazinone, 1 , was synthesized in six steps from ethyl (1,2,3,4‐ 13 C 4 )acetoacetate and ( 15 N)ammonium hydroxide. A total of 1.3 g [ 13 C 4 , 15 N 2 ]pyrrolotriazinone was obtained in an overall yield of 17% based on isotopic ethyl acetoacetate. Chemical purity was determined by HPLC to be 99.5%. The percent [ 13 C, 15 N]‐isotopic abundance in [ 13 C 4 , 15 N 2 ]pyrrolotriazinone was determined by mass spectral analysis to be 98.0%. The fully assigned 1 H and 13 C NMR spectra of [ 13 C 4 , 15 N 2 ]pyrrolotriazinone were consistent with the desired structure. Copyright © 2006 John Wiley & Sons, Ltd.