Synthesis of [ 13 C 4 , 15 N 2 ]pyrrolo[2,1‐ f ][1,2,4]triazinone | Zendy

Ogan Marc D. | Zendy; Tran Scott Bach | Zendy; Rinehart J. Kent | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis of [ 13 C 4 , 15 N 2 ]pyrrolo[2,1‐ f ][1,2,4]triazinone

Author(s) -

Ogan Marc D.,

Tran Scott Bach,

Rinehart J. Kent

Publication year - 2006

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1030

Subject(s) - chemistry , ethyl acetoacetate , yield (engineering) , ammonium hydroxide , organic chemistry , catalysis , materials science , metallurgy

[ 13 C 4 , 15 N 2 ]Pyrrolotriazinone, 1 , was synthesized in six steps from ethyl (1,2,3,4‐ 13 C 4 )acetoacetate and ( 15 N)ammonium hydroxide. A total of 1.3 g [ 13 C 4 , 15 N 2 ]pyrrolotriazinone was obtained in an overall yield of 17% based on isotopic ethyl acetoacetate. Chemical purity was determined by HPLC to be 99.5%. The percent [ 13 C, 15 N]‐isotopic abundance in [ 13 C 4 , 15 N 2 ]pyrrolotriazinone was determined by mass spectral analysis to be 98.0%. The fully assigned 1 H and 13 C NMR spectra of [ 13 C 4 , 15 N 2 ]pyrrolotriazinone were consistent with the desired structure. Copyright © 2006 John Wiley & Sons, Ltd.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research