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A facile and efficient synthesis of d 3 ‐labelled Reyataz™
Author(s) -
Zhang Huiping,
Bonacorsi Samuel J.,
Chen BangChi,
Leith Leslie W.,
Kent Rinehart J.,
Balasubramanian Balu,
Barrish Joel C.
Publication year - 2005
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1019
Subject(s) - chemistry , combinatorial chemistry , radiochemistry , stereochemistry
A facile and efficient synthesis of d 3 ‐labelled Reyataz™ is described. The key step of synthesis involved the coupling of N ‐(d 3 ‐methoxycarbonyl)‐ L ‐ tert ‐leucine 2b with an advanced chiral non‐racemic building block 4 . The latter was synthesized in 4 steps from the readily accessible hydrazine derivative 8 . Copyright © 2005 John Wiley & Sons, Ltd.