Carbon‐14 labelling of selective H 3  receptor antagonists | Zendy

Johansen Steen K. | Zendy

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Carbon‐14 labelling of selective H 3 receptor antagonists

Author(s) -

Johansen Steen K.

Publication year - 2005

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1018

Subject(s) - chemistry , labelling , malonic acid , knoevenagel condensation , yield (engineering) , carbon 14 , carbon fibers , stereochemistry , specific activity , organic chemistry , biochemistry , catalysis , algorithm , materials science , physics , quantum mechanics , composite number , computer science , metallurgy , enzyme

The fast and efficient carbon‐14 labelling of the three potent H 3 antagonists NNC 38‐1202, NNC 38‐1384, and NNC 38‐1401 is reported. The two‐step synthetic sequence, which included a Knoevenagel reaction, provided the carbon‐14‐labelled compounds in 38–55% overall yield starting from [2‐ 14 C]malonic acid. The compounds were all obtained in high radiochemical purity ( > 99%) and with high specific activity (55.8 mCi/mmol). Copyright © 2005 John Wiley & Sons, Ltd.

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