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High specific activity tritium labeling of vitamin D derivative RO275646
Author(s) -
de Keczer Steve A.,
Lane Tim S.,
Voronin Tatyana,
Masjedizadeh Mohammad R.
Publication year - 2005
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1014
Subject(s) - chemistry , tritium , specific activity , derivative (finance) , radiochemistry , tritium illumination , vitamin d and neurology , isotope , chromatography , organic chemistry , medicine , nuclear physics , physics , financial economics , economics , enzyme
The octahydroindenone intermediate was tritium labeled using T 2 O isotope exchange labeling, and then elaborated to the vitamin D derivative RO275646. Though this method of labeling was expected to give the minor isomer, it was the shortest and most convenient route to the high specific activity metabolically stable labeled sites. A total of 34 mCi (from two separate runs) at 64 Ci/mmol of [ 3 H]‐RO275646 were prepared by this method. Copyright © 2005 John Wiley & Sons, Ltd.