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The role of IL‐20 in chronic kidney disease and diabetic nephropathy: Pathogenic and therapeutic implications
Author(s) -
Chang MingShi,
Hsu YuHsiang
Publication year - 2018
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.mr1217-489r
Subject(s) - proinflammatory cytokine , diabetic nephropathy , kidney disease , immunology , medicine , nephropathy , kidney , inflammation , diabetes mellitus , endocrinology
Chronic kidney disease and its complications are a major public health problem worldwide. Diabetic nephropathy has become the main contributing cause of terminal renal failure. There are now evidences that different inflammatory molecules, including proinflammatory cytokines, play a critical role in the development of microvascular diabetic complications, including nephropathy. IL‐20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, and renal failure. This review discusses the role of IL‐20 as a pathogenic factor in renal injury, focusing on chronic kidney disease and diabetic nephropathy, and describes potential treatment strategies based on modulation of IL‐20's function.