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IL‐4Rα‐expressing CD11c + cells contribute to driving optimal cellular responses during Schistosoma mansoni infection in mice
Author(s) -
Ndlovu Hlumani,
o Justin Komguep,
Nieuwenhuizen Natalie Eva,
Brombacher Frank
Publication year - 2019
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.ma0318-115r
Subject(s) - cd11c , biology , schistosoma mansoni , immunology , immunity , secretion , effector , schistosomiasis , cellular immunity , microbiology and biotechnology , t cell , immune system , phenotype , endocrinology , helminths , gene , biochemistry
Development of IL‐4 receptor alpha (IL‐4Rα)‐dependent cellular immunity regulates host protection against acute schistosomiasis. In this study, we investigated the importance of IL‐4Rα‐expressing CD11c + cells in driving the development of optimal cellular responses to Schistosoma mansoni infection by using CD11c cre IL‐4Rα −/lox BALB/c mice, which lacked IL‐4Rα expression on dendritic cells and alveolar macrophages. Abrogation of IL‐4Rα expression on CD11c + cells affected activation of CD4 + T cells, resulting in reduced numbers of effector CD4 + T cells and impaired production of Th1 and Th2 cytokines by CD4 + T cells ex vivo. However, secretion of both type 1 and type 2 Ab isotypes was unchanged in infected CD11c‐specific IL‐4Rα‐deficient mice compared to littermate controls. Together, these data demonstrate that IL‐4Rα‐expressing CD11c + cells play an important role in maintaining cellular immunity during schistosomiasis in mice.