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Exploitation of host cell signaling machinery: activation of macrophage phosphotyrosine phosphatases as a novel mechanism of molecular microbial pathogenesis
Author(s) -
Nandan Devki,
Knutson Keith L.,
Lo Raymond,
Reiner Neil E.
Publication year - 2000
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.67.4.464
Subject(s) - biology , pathogenesis , intracellular , intracellular parasite , microbiology and biotechnology , signal transduction , mycobacterium tuberculosis , protein tyrosine phosphatase , macrophage , leishmania donovani , cell signaling , immunology , tuberculosis , in vitro , leishmaniasis , genetics , visceral leishmaniasis , medicine , pathology
Abstract Intracellular pathogens, particularly those that target host mononuclear phagocytes, have evolved strategies to either evade or inhibit cellular mechanisms of host defense. Mycobacterium tuberculosis and Leishmania donovani exemplify a diverse group of microorganisms that have developed the ability to invade and replicate within host macrophages, leading to disease expression. Recent studies have suggested that the pathogenesis of intracellular infection may involve interference with host cell signaling. Drawing upon examples from in vitro models that focused on M. tuberculosis and L. donovani , we review evidence that activation of host cell phosphotyrosine phosphatases may contribute to pathogenesis. A leading candidate appears to be the Src homology 2 domain containing phosphotyrosine phosphatase SHP‐1, the activation of which may contribute to the development of infection and disease progression. J. Leukoc. Biol. 67: 464‐470; 2000.