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Immune response to infection with Salmonella typhimurium in mice
Author(s) -
Mittrücker HansWilli,
Kaufmann Stefan H. E.
Publication year - 2000
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.67.4.457
Subject(s) - biology , salmonella , immune system , immunity , microbiology and biotechnology , antibody , salmonella infection , immunology , innate immune system , antigen , salmonella typhi , intracellular parasite , virology , bacteria , escherichia coli , genetics , gene , biochemistry
Infection of mice with Salmonella typhimurium results in systemic infection and a disease similar to that seen in humans after infection with S. typhi. The innate immune system can restrict replication of S. typhimurium to a certain degree, but for effective control and eradication of bacteria, acquired immunity is essential. Salmonella infection induces the generation of specific CD4 + and CD8 + T cells, and both T cell populations are important for protection during primary and secondary responses, although the mechanisms underlying T cell‐mediated protection are not yet completely understood. Infection with S. typhimurium also results in a strong antibody response to Salmonella antigens and, in contrast to most other intracellular bacteria, this antibody response participates in protection. In summary, the response to S. typhimurium involves both T and B cell‐mediated immunity, and mechanisms mediated by both lymphocyte populations are important for control of primary infection and protection against secondary infection. J. Leukoc. Biol. 67: 457–463; 2000.