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The peroxisome proliferator‐activated receptorγ (PPARγ) as a regulator of monocyte/macrophage function
Author(s) -
Ricote Mercedes,
Huang Jannet T.,
Welch John S.,
Glass Christopher K.
Publication year - 1999
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.66.5.733
Subject(s) - peroxisome proliferator activated receptor , biology , regulator , monocyte , macrophage , microbiology and biotechnology , function (biology) , receptor , peroxisome , peroxisome proliferator , peroxisome proliferator activated receptor alpha , peroxisome proliferator activated receptor gamma , cancer research , nuclear receptor , immunology , transcription factor , biochemistry , in vitro , gene
Abstract Peroxisome proliferator‐activated receptors (PPARs) are ligand‐dependent transcription factors of the nuclear hormone receptor superfamily, which includes the steroid, retinoid, and thyroid hormone receptors. The PPARs can be activated by fatty acids and their eicosanoid metabolites, and have until recently been considered primarily to regulate genes involved in glucose and lipid homeostasis. In the past year there has been an explosive increase in research implicating PPARγ in macrophage biology, cell cycle regulation, and atherosclerosis. This review describes recent insights into the role of PPARγ in the macrophage lineage, and its potential function in the regulation of inflammatory responses and atherosclerosis. J. Leukoc. Biol. 66: 733–739; 1999.