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Inhibitory and activating receptors involved in immune surveillance by human NK and myeloid cells
Author(s) -
Colonna Marco,
Nakajima Hideo,
Cella Marina
Publication year - 1999
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.66.5.718
Subject(s) - biology , myeloid cells , receptor , immune system , myeloid , immunology , immune surveillance , inhibitory postsynaptic potential , microbiology and biotechnology , neuroscience , genetics
We review the structure, cellular distribution, ligand specificity, and function of two emerging types of receptors involved in natural killer (NK) and myeloid cell recognition of other cells: ILT/LIR/MIR and 2B4 receptors. ILT/LIR/MIR receptors are differentially expressed on lymphoid and myeloid cells and two of them, ILT2 and ILT4, recognize HLA class I molecules. Whereas some receptors inhibit, others induce cell activation. 2B4 is broadly expressed on leukocytes, binds CD48, and mediates non‐MHC‐restricted cytotoxicity by NK cells. J. Leukoc. Biol. 66: 718–722; 1999.