Inhibitory and activating receptors involved in immune surveillance by human NK and myeloid cells | Zendy

Colonna Marco | Zendy; Nakajima Hideo | Zendy; Cella Marina | Zendy

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Inhibitory and activating receptors involved in immune surveillance by human NK and myeloid cells

Author(s) -

Colonna Marco,

Nakajima Hideo,

Cella Marina

Publication year - 1999

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1002/jlb.66.5.718

Subject(s) - biology , myeloid cells , receptor , immune system , myeloid , immunology , immune surveillance , inhibitory postsynaptic potential , microbiology and biotechnology , neuroscience , genetics

We review the structure, cellular distribution, ligand specificity, and function of two emerging types of receptors involved in natural killer (NK) and myeloid cell recognition of other cells: ILT/LIR/MIR and 2B4 receptors. ILT/LIR/MIR receptors are differentially expressed on lymphoid and myeloid cells and two of them, ILT2 and ILT4, recognize HLA class I molecules. Whereas some receptors inhibit, others induce cell activation. 2B4 is broadly expressed on leukocytes, binds CD48, and mediates non‐MHC‐restricted cytotoxicity by NK cells. J. Leukoc. Biol. 66: 718–722; 1999.

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