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Role of cytokines in epidermal Langerhans cell migration
Author(s) -
Wang Binghe,
Amerio Paolo,
Sauder Daniel N.
Publication year - 1999
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.66.1.33
Subject(s) - proinflammatory cytokine , chemokine , immunology , biology , cytokine , epidermis (zoology) , antigen presenting cell , lymphatic system , dendritic cell , immune system , antigen presentation , microbiology and biotechnology , tumor necrosis factor alpha , langerhans cell , t cell , inflammation , anatomy
In the epidermal compartment of skin, keratinocytes (KC), Langerhans cells (LC), and their soluble products, i.e. cytokines, constitute a unique immunologic microenvironment. KC participate in cutaneous immune responses by producing various cytokines. LC, a member of the dendritic cell (DC) family, represent the professional antigen‐presenting cells in the epidermis. Although it has been demonstrated that migration of LC from skin to lymph nodes is a critical step for the antigen presentation, molecular mechanisms for such an event remain unclear. Recent studies suggest that cytokines are able to modulate LC/DC migration. There is accumulating evidence that proinflammatory cytokines including interleukin (IL)‐1 and tumor necrosis factor a promote LC emigration from the skin, whereas the anti‐inflammatory cytokine IL‐10 is a counter‐regulator. LC/DC express chemokine receptors. Chemokines generated from lymphatic endothelial cells and lymph node cells play a role in the directional migration of LC/DC into lymph nodes. This article reviews current studies on the role of cytokines in LC/DC migration. J. Leukoc. Biol. 66: 33–39; 1999.
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