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Inflammation of the brain in Alzheimer's disease: implications for therapy
Author(s) -
McGeer Patrick L.,
McGeer Edith G.
Publication year - 1999
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.65.4.409
Subject(s) - inflammation , microglia , disease , neuroscience , complement (music) , immunology , immune system , neuroinflammation , complement system , biology , alzheimer's disease , medicine , pathology , biochemistry , complementation , gene , phenotype
We briefly describe the similarities and differences between a systemic and a local immune reaction and review the evidence that the latter occurs in Alzheimer's disease (AD) brains. The evidence comes mainly from studies on the complement system, microglia, and cytokines, all of which are important actors in the inflammatory process. The evidence is now overwhelming that the complement proteins and many of the mediators of inflammation are produced locally by brain cells. We will mention briefly the many epidemiological studies indicating that the use of anti‐inflammatory drugs reduces the incidence and slows the progress of AD. Mention will also be made of some recent work on animal models of possible relevance to AD and inflammation. J. Leukoc. Biol. 65: 409–415; 1999.