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CD43 is associated with tyrosine kinase activity in human neutrophils
Author(s) -
Skubitz Keith M.,
Campbell Kenneth D.,
Skubitz Amy P. N.
Publication year - 1998
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.64.6.800
Subject(s) - lyn , tyrosine protein kinase csk , proto oncogene tyrosine protein kinase src , tyrosine kinase , biology , signal transduction , microbiology and biotechnology , receptor tyrosine kinase , kinase , ask1 , cd43 , protein kinase c , mitogen activated protein kinase kinase , cancer research , sh2 domain , antigen , immunology , cd20
CD43 appears to be involved in signal transduction, however, the mechanism of this function is unknown. Protein kinase activity was detected in neutrophils associated with CD43. Most of the protein kinase activity associated with these antigens was tyrosine kinase activity. The src family kinases lyn and hck were found to account for much of the associated tyrosine kinase activity. The data suggest that associated tyrosine kinase activity may play a role in signal transduction via CD43 to regulate other cell functions. J. Leukoc. Biol. 64: 800–802; 1998.