HIV load in highly purified CD8 +  T cells retrieved from pulmonary and blood compartments | Zendy

Semenzato Gianpietro | Zendy; Agostini Carlo | Zendy; ChiecoBianchi Luigi | Zendy; De Rossi Anita | Zendy

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HIV load in highly purified CD8 + T cells retrieved from pulmonary and blood compartments

Author(s) -

Semenzato Gianpietro,

Agostini Carlo,

ChiecoBianchi Luigi,

De Rossi Anita

Publication year - 1998

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1002/jlb.64.3.298

Subject(s) - biology , cd8 , bronchoalveolar lavage , immunology , immune system , lung , viral load , ctl* , cytotoxic t cell , t cell , asymptomatic , peripheral blood mononuclear cell , peripheral blood , virus , virology , pathology , medicine , biochemistry , in vitro

The pulmonary microenvironment can be HIV infected from the asymptomatic period of HIV infection and it has been demonstrated that HIV presence elicits a discrete virus‐specific CTL immune response in the lungs. In this study we analyzed T cell subsets and compared the proportion of CD8 + T cells harboring HIV in the lung and in the circulation of HIV‐seropositive patients with T cell alveolitis. Proviral load was assessed using the DNA‐polymerase chain reaction technique on highly purified CD8 + T cells isolated from peripheral blood and bronchoalveolar lavage. The proviral load of pulmonary CD8 + T cells showed an upward trend with respect to corresponding samples isolated from the peripheral blood of the same patients. J. Leukoc. Biol . 64: 298–301; 1998.

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