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T h 1 and T h 2 cytokines cooperate to stimulate mannose‐receptor‐mediated phagocytosis
Author(s) -
Raveh David,
Kruskal Benjamin A.,
Farland Julien,
Ezekowitz R. Alan B.
Publication year - 1998
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.64.1.108
Subject(s) - mannose receptor , endocytosis , phagocytosis , biology , receptor , microbiology and biotechnology , mannose , interleukin 10 , cytokine , cytokine receptor , receptor mediated endocytosis , receptor expression , immunology , macrophage , biochemistry , in vitro
Abstract The mannose receptor is a macrophage surface receptor that mediates both endocytosis and phagocytosis. Previous work has demonstrated that the prototypical T h 2 cytokine, interleukin‐4 (IL‐4), increases both cell‐surface receptor expression and mannose receptor‐mediated endocytosis, whereas the prototypical T h 1 cytokine, interferon‐γ (IFN‐γ), decreases both surface expression and endocytosis. In many aspects of the immune response, T h 1 and T h 2 cytokines oppose each others' actions. We demonstrate that IL‐4 and IFN‐γ alone and together enhance mannose receptor‐mediated phagocytosis, despite opposing effects on cell‐surface mannose receptor expression and endocytosis. Thus these usually antagonistic cytokines cooperate in increasing mannose receptor phagocytic function. The cooperative effect of these cytokines is not observed for Fc receptor‐mediated phagocytosis. The T h 2 cytokine IL‐13 exerts similar effects to IL‐4. Our results suggest that T h 1 and T h 2 cytokines may act in concert at sites of inflammation to enhance mannose receptor‐mediated phagocytosis of microorganisms. J. Leukoc. Biol . 64: 108–113; 1998.