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Transcriptional regulation in the immune system: all roads lead to AP‐1
Author(s) -
Foletta Victoria C.,
Segal David H.,
Cohen Donna R.
Publication year - 1998
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.63.2.139
Subject(s) - biology , immune system , transcription factor , microbiology and biotechnology , activator (genetics) , regulator , regulation of gene expression , gene , transcriptional regulation , signal transduction , gene expression , immunology , genetics
The mechanisms regulating the development and function of the immune system are diverse and complicated. The signaling pathways and target genes that become activated upon cell‐surface stimulation are currently being defined, and transcription factor activator protein 1 (AP‐1) is proving to be an important regulator of nuclear gene expression in leukocytes. In vitro and in vivo studies have demonstrated that AP‐1 expression is induced after a diverse range of stimuli and that AP‐1 contributes to the regulation of a large number of genes. In this review we will examine the role of AP‐1 during leukocyte activation and differentiation in the immune system. J. Leukoc. Biol . 63: 139–152; 1998.