Adenosine A 3  receptor stimulation inhibits migration of human eosinophils | Zendy

Knight Darryl | Zendy; Zheng Xueyan | Zendy; Rocchini Corinne | Zendy; Jacobson Marlene | Zendy; Bai Tony | Zendy; Walker Blair | Zendy

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Adenosine A 3 receptor stimulation inhibits migration of human eosinophils

Author(s) -

Knight Darryl,

Zheng Xueyan,

Rocchini Corinne,

Jacobson Marlene,

Bai Tony,

Walker Blair

Publication year - 1997

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1002/jlb.62.4.465

Subject(s) - chemotaxis , leukotriene b4 , stimulation , eosinophil , biology , adenosine , receptor , platelet activating factor , microbiology and biotechnology , inflammation , immunology , medicine , endocrinology , biochemistry , asthma

Activation of adenosine A 3 receptors (A 3 ‐R) produced a dose‐dependent reduction in the chemotaxis of human eosinophils to platelet‐activating factor (PAF), RANTES, and leukotriene B 4 (LTB 4 ) to a maximum of 58,48, and 52%, respectively ( P < 0.02). This effect was completely reversed by selective A 3 ‐R antagonists. In contrast, activation of A 1 or A 2a ‐R did not affect PAF‐induced eosinophil chemotaxis. PAF upregulated the expression of CD11b/CD18, down‐regulated L‐selectin, and also increased F‐actin assembly in eosinophils. The expression of these activation markers was not influenced by A 3 ‐R, A2a, or A 1 ‐R stimulation. Activation of A 3 ‐R may play an important role in inflammation by inhibiting eosinophil migration. J. Leukoc. Biol. 62: 465–468; 1997.

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