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Human neutrophils secrete vascular endothelial growth factor
Author(s) -
Taichman Norton S.,
Young Sylvia,
Cruchley Alan T.,
Taylor Peter,
Paleolog Ewa
Publication year - 1997
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.62.3.397
Subject(s) - biology , secretion , vascular endothelial growth factor , microbiology and biotechnology , immunology , growth factor , vegf receptors , endocrinology , cancer research , biochemistry , receptor
Vascular endothelial growth factor (VEGF) is a multifunctional cytokine that plays a pivotal role in mediating neovascularization as well as other endothelial cell alterations during inflammation. In this study, we demonstrate that human neutrophils are a source of VEGF. We observed that isolated blood neutrophils released VEGF in response to different stimuli and we demonstrated by immunohistochemistry that neutrophils infiltrating inflamed tissues contain VEGF. These results indicate that neutrophil‐derived VEGF may be instrumental in regulating vascular responses during acute and chronic inflammation. J. Leukoc. Biol. 62: 397–400; 1997.