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γδ T cell activation or anergy during infections: the role of nonpeptidic TCR ligands and HLA class I molecules
Author(s) -
Poccia Fabrizio,
Malkovsky Miroslav,
Gougeon Marie Lise,
Bonneville Marc,
LopezBotet Miguel,
Fournié Jean Jacques,
Colizzi Vittorio
Publication year - 1997
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.62.3.287
Subject(s) - biology , t cell receptor , immunology , human leukocyte antigen , t cell , microbiology and biotechnology , immune system , antigen
Vγ9Vδ2‐encoded T cell receptors (TCR) expressed by most human peripheral blood γδ T cells mediate the recognition of nonpeptidic phosphoantigens from various pathogens without any known requirement for HLA molecules. Functionally mature Vγ9Vδ2 T cells display a potent natural killer (NK) ‐like cytotoxic activity, share with NK cells the expression of inhibitory receptors for HLA class I molecules, and release a plethora of cytokines, most notably interferon‐γ and tumor necrosis factor α. Hence, through local activation, the early recruitment and stimulation of Vγ9Vδ2 T cells may promote efficient anti‐infectious immunity. However, a chronic overactivation of this T cell subset may result in immunopathology. The meeting held in St. Vincent, Val d'Aosta, Italy (symposium on γδ T cells in natural immunity to infections: a rationale for vaccine development organized by the World Foundation for AIDS Research and Prevention, the UNESCO, and the Italian National Research Council, December 2–4,1996) focused on the importance of γδ T cell activation and anergy for the pathogenesis of tuberculosis, malaria, and HIV infections. J. Leukoc. Biol. 62: 287–291; 1997.