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Apoptosis in resolution of inflammation
Author(s) -
Savill John
Publication year - 1997
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.61.4.375
Subject(s) - apoptosis , inflammation , biology , programmed cell death , microbiology and biotechnology , pathogenesis , macrophage , immunology , efferocytosis , cancer research , in vitro , genetics
The last few years have seen the accumulation of compelling evidence that apoptosis (programmed cell death) plays a major role in promoting resolution of the acute inflammatory response. Neutrophils are constitutively programmed to undergo apoptosis, which limits their pro‐inflammatory potential and leads to rapid, specific, and non‐phlogistic recognition by macrophages and semi‐professional phagocytes. Similar mechanisms have been implicated in clearance of eosinophils, lymphocytes, and monocytes and apoptosis also plays a role in remodeling the inflamed site by deletion of myofibroblasts. A growing understanding of the mechanisms regulating leukocyte apoptosis and of the molecules mediating safe phagocytic clearance of dying cells may yield new insights into the pathogenesis and therapy of inflammatory diseases. J. Leukoc. Biol . 61: 375–380; 1997.