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The inflammatory macrophage response to MCMV in mice with a retroviral immunodeficiency syndrome (MAIDS)
Author(s) -
Allcock Richard J.N.,
Peacock Craig D.,
Price Patricia
Publication year - 1996
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.60.1.44
Subject(s) - biology , macrophage , tumor necrosis factor alpha , inflammation , peritoneal cavity , immunology , virology , in vitro , biochemistry , anatomy
We have shown that normal C57BL/6J mice are moderately resistant to infection with murine cytomegalovirus (MCMV) and that this resistance is impaired by prior infection with LP‐BM5 MuLV, which causes a disease (MAIDS) similar to early HIV‐induced disease. This study investigates macrophage function in MAIDS + mice challenged with MCMV. MAIDS reduces the influx of cells into the peritoneal cavity seen in normal C57BL/6J mice 6 days after MCMV infection. The infiltrates contained cells that resembled activated macrophages, as they took up colloidal gold, expressed the macrophage marker Mac‐1, had high levels of acid phosphatase activity, and were lymphocytostatic when co‐cultured with activated T cells. MAIDS + mice had a higher percentage of cells able to take up colloidal gold and higher acid phosphatase activity per cell. The cells were also more lymphocytostatic and produced higher levels of interleukin‐1 and tumor necrosis factor‐α on days 4 and 6 after MCMV infection. Hence, MAIDS enhances baseline and induced macrophage activity, but depresses infiltration into the site of inflammation.