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Complement factor and T‐cell interactions during alloimmune inflammation in transplantation
Author(s) -
Khan Mohammad Afzal,
Shamma Talal
Publication year - 2019
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.5ru0718-288r
Subject(s) - inflammation , complement system , biology , immunology , transplantation , immune system , complement factor i , effector , organ transplantation , factor h , c5a receptor , alternative complement pathway , transplant rejection , medicine , surgery
Complement factor and T‐cell signaling during an effective alloimmune response plays a key role in transplant‐associated injury, which leads to the progression of chronic rejection (CR). During an alloimmune response, activated complement factors (C3a and C5a) bind to their corresponding receptors (C3aR and C5aR) on a number of lymphocytes, including T‐regulatory cells (Tregs), and these cell‐molecular interactions have been vital to modulate an effective immune response to/from Th1‐effector cell and Treg activities, which result in massive inflammation, microvascular impairments, and fibrotic remodeling. Involvement of the complement‐mediated cell signaling during transplantation signifies a crucial role of complement components as a key therapeutic switch to regulate ongoing inflammatory state, and further to avoid the progression of CR of the transplanted organ. This review highlights the role of complement‐T cell interactions, and how these interactions shunt the effector immune response during alloimmune inflammation in transplantation, which could be a novel therapeutic tool to protect a transplanted organ and avoid progression of CR.