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Regulatory B cells and advances in transplantation
Author(s) -
Li Jinfeng,
Luo Yongsheng,
Wang Xu,
Feng Guiwen
Publication year - 2019
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.5ru0518-199r
Subject(s) - regulatory b cells , biology , transplantation , immune system , adoptive cell transfer , immunology , transplant rejection , interleukin 10 , immunotherapy , function (biology) , cancer research , microbiology and biotechnology , t cell , medicine
The effects of B cell subsets with regulatory activity on the immune response to an allograft have evoked increasing interest. Here, we summarize the function and signaling of regulatory B cells (Bregs) and their potential effects on transplantation. These cells are able to suppress the immune system directly via ligand–receptor interactions and indirectly by secretion of immunosuppressive cytokines, particularly IL‐10. In experimental animal models, the extensively studied IL‐10‐producing B cells have shown unique therapeutic advantages in the transplant field. In addition, adoptive transfer of B cell subsets with regulatory activity may reveal a new approach to prolonging allograft survival. Recent clinical observations on currently available therapies targeting B cells have revealed that Bregs play an important role in immune tolerance and that these cells are expected to become a new target of immunotherapy for transplant‐related diseases.