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γδ cells and tumor microenvironment: A helpful or a dangerous liason?
Author(s) -
Lo Presti Elena,
Di Mitri Roberto,
Pizzolato Gabriele,
Mocciaro Filippo,
Dieli Francesco,
Meraviglia Serena
Publication year - 2018
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.5mr0717-275rr
Subject(s) - immunosurveillance , tumor microenvironment , biology , adoptive cell transfer , cancer research , in vivo , immunology , immunotherapy , tumor cells , population , t cell , in vitro , immune system , medicine , microbiology and biotechnology , environmental health , biochemistry
γδ T cells are a subset of T lymphocytes that have been implicated in immunosurveillance against infections and tumors. γδ T cells are endowed with antitumor activities, and hence several γδ T cell‐based small‐scale clinical trials have been conducted either by in vivo activation by intravenous administration of aminobiphosphonates or by adoptive transfer of in vitro expanded γδ T cells. Although both these strategies have yielded promising results, there are a number of limitations associated with each of them which, if overcome may help to further improve efficacy. One of the most important limits is the possible polarization of tumor‐infiltrating γδ T cells toward different γδ T cells population with functional activities that help the progression and spread of the tumor. Here, we review the modalities and the possible mechanisms involved in the polarization of tumor‐infiltrating γδ T cells upon interaction with several components of the tumor microenvironment and discuss their implications for the manipulation of γδ T cells in cancer immunotherapy.