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Impact of age‐, cancer‐, and treatment‐driven inflammation on T cell function and immunotherapy
Author(s) -
Quinn Kylie M.,
Kartikasari Apriliana E. R.,
Cooke Rachel E.,
Koldej Rachel M.,
Ritchie David S.,
Plebanski Magdalena
Publication year - 2020
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.5mr0520-466r
Subject(s) - inflammation , cancer , immune system , immunotherapy , disease , immunology , ovarian cancer , cancer immunotherapy , oncology , medicine , biology , bioinformatics
Many cancers are predominantly diagnosed in older individuals and chronic inflammation has a major impact on the overall health and immune function of older cancer patients. Chronic inflammation is a feature of aging, it can accelerate disease in many cancers and it is often exacerbated during conventional treatments for cancer. This review will provide an overview of the factors that lead to increased inflammation in older individuals and/or individuals with cancer, as well as those that result from conventional treatments for cancer, using ovarian cancer (OC) and multiple myeloma (MM) as key examples. We will also consider the impact of chronic inflammation on immune function, with a particular focus on T cells as they are key targets for novel cancer immunotherapies. Overall, this review aims to highlight specific pathways for potential interventions that may be able to mitigate the impact of chronic inflammation in older cancer patients.