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What a difference ADA2 makes: Insights into the pathophysiology of ADA2 deficiency from single‐cell RNA sequencing of monocytes
Author(s) -
Ehlers Lisa,
Meyts Isabelle
Publication year - 2021
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.5ce0421-186r
Subject(s) - biology , rna , pathophysiology , gene , monocyte , immunology , gene expression , inflammation , microbiology and biotechnology , genetics , endocrinology
Graphical Abstract Discussion on the increase in nonclassical monocytes in patients with DADA2 as shown by scRNA seq; these pro inflammatory cells also show increased TNFR2, type I, and type II IFN pathway gene expression.