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CD71+ erythroid cells from neonates born to women with preterm labor regulate cytokine and cellular responses
Author(s) -
Miller Derek,
Romero Roberto,
Unkel Ronald,
Xu Yi,
VadilloOrtega Felipe,
Hassan Sonia S.,
GomezLopez Nardhy
Publication year - 2018
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.5a0717-291rrr
Subject(s) - biology , proinflammatory cytokine , transferrin receptor , cytokine , immunology , immune system , peripheral blood mononuclear cell , cd8 , myeloid , microbiology and biotechnology , t cell , endocrinology , transferrin , inflammation , genetics , in vitro
Neonatal CD71+ erythroid cells are thought to have immunosuppressive functions. Recently, we demonstrated that CD71+ erythroid cells from neonates born to women who underwent spontaneous preterm labor (PTL) are reduced to levels similar to those of term neonates; yet, their functional properties are unknown. Herein, we investigated the functionality of CD71+ erythroid cells from neonates born to women who underwent spontaneous preterm or term labor. CD71+ erythroid cells from neonates born to women who underwent PTL displayed a similar mRNA profile to that of those from term neonates. The direct contact between preterm or term neonatal CD71+ erythroid cells and maternal mononuclear immune cells, but not soluble products from these cells, induced the release of proinflammatory cytokines and a reduction in the release of TGF‐β. Moreover, PTL‐derived neonatal CD71+ erythroid cells (1) modestly altered CD8+ T cell activation; (2) inhibited conventional CD4+ and CD8+ T‐cell expansion; (3) suppressed the expansion of CD8+ regulatory T cells; (4) regulated cytokine responses mounted by myeloid cells in the presence of a microbial product; and (5) indirectly modulated T‐cell cytokine responses. In conclusion, neonatal CD71+ erythroid cells regulate neonatal T‐cell and myeloid responses and their direct contact with maternal mononuclear cells induces a proinflammatory response. These findings provide insight into the biology of neonatal CD71+ erythroid cells during the physiologic and pathologic processes of labor.