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Colony stimulating factor‐1 expression is developmentally regulated in the mouse
Author(s) -
Roth Philip,
Stanley E. Richard
Publication year - 1996
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.59.6.817
Subject(s) - biology , fetus , medicine , endocrinology , kidney , lung , gestational age , spleen , mononuclear phagocyte system , andrology , pregnancy , immunology , genetics
Colony stimulating factor‐1 (CSF‐1) regulates the survival, proliferation, and differentiation of mononuclear phagocytes. To determine whether CSF‐1 plays a role in the perinatal development of these cells, CSF‐1 protein and mRNA expression in tissues and serum from fetal/neonatal mice and their mothers was analyzed. As fetal/neonatal age increased, CSF‐1 concentrations rose in liver, kidney, and lung, declined in brain and serum, and did not change in intestine and heart. Concurrently, fetal/neonatal CSF‐1 concentrations were higher in liver, kidney, and serum and lower in lung, brain, intestine, and heart than maternal tissue/serum concentrations, which showed no correlations with gestational or post‐partum stage. CSF‐1 mRNA was detected in all tissues examined and its expression increased in lung and heart and decreased in brain with increasing fetal/neonatal age. The developmental regulation of mouse CSF‐1 expression appears to be important for mononuclear phagocyte development during this period.