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Membrane phospholipid asymmetry: host response to the externalization of phosphatidylserine
Author(s) -
Bruckheimer Elizabeth M.,
Schroit Alan J.
Publication year - 1996
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.59.6.784
Subject(s) - phosphatidylserine , biology , microbiology and biotechnology , phospholipid , phospholipid scramblase , homeostasis , cell membrane , cell , phosphatidylethanolamine , biochemistry , membrane , phosphatidylcholine
Membrane phospholipid asymmetry is an important regulator of cellular function and homeostasis. The activities of lipid transporters are contributing factors to the regulation of membrane lipid composition over the lifespan of the cell. Alterations in the activites of these proteins result in the movement of phosphatidylserine to the cell's outer leaflet. This promotes several physiologic responses including initiation of the coagulation cascade and cell recognition by the reticuloendothelial system.