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IL‐13 restores an in vitro specific cytolytic response of spleen cells from tumor‐bearing rats
Author(s) -
Reisser Danièle,
Pinard Dominique,
Jeannin JeanFrançois
Publication year - 1996
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.59.5.728
Subject(s) - cytotoxic t cell , cytolysis , spleen , biology , in vitro , cytotoxicity , antigen , cancer research , immunology , microbiology and biotechnology , biochemistry
In a model of colon cancer, spleen cells from tumor‐bearing rats are neither cytotoxic nor proliferative in vitro in the presence of tumor cells. Interleukin‐13 (IL‐13) induced an in vitro cytolytic activity of spleen cells from tumor‐bearing rats in response to the tumor they bore, but had no effect on spleen cells from normal rats. This cytotoxic response was dependent on both adherent and nonadherent cells, involving both an antigen‐presenting activity that was enhanced by IL‐13 and a cytolytic activity of lymphocytes. So, IL‐13 reversed the tumor‐induced immunosuppression.