Premium
Dendritic cells from different tissues induce production of different T cell cytokine profiles
Author(s) -
Everson Michael P.,
McDuffie Deborrah S.,
Lemak David G.,
Koopman William J.,
McGhee Jerry R.,
Beagley Kenneth W.
Publication year - 1996
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.59.4.494
Subject(s) - biology , cytokine , immune system , immunology , microbiology and biotechnology , antigen presenting cell , dendritic cell , t cell , t helper cell
The precise role of antigen‐presenting cells (APC) in regulating the balance of T‐helper type 1 (Th1) and T‐helper type 2 (Th2) cytokine production is unclear. Dendritic cells (DC), the most potent APC for activation of naive T cells, were found to regulate Th1 and Th2 cytokine profiles in a fashion dependent upon their tissue of origin. Spleen (systemic) DC induce mainly Th1 cytokines and Peyer's patch (mucosal) DC induce predominantly Th2 cytokines. These findings support the current concept that different tissues, each with its distinct microenvironment of cytokines, hormones, and cellular elements, are involved in the selection, promotion, and/or maintenance of different immune responses. With regard to DC, it is apparent that the tissue of DC origin determines the cytokine profiles produced by T cells and that DC from different tissues favor either cellular versus humoral immune responses by influencing T cell cytokine production.