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Examination of the mononuclear phagocyte system in lupus‐prone male BXSB mice
Author(s) -
Vieten G.,
Grams B.,
Müller M.,
Hartung K.,
Emmendörffer A.
Publication year - 1996
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.59.3.325
Subject(s) - monocytosis , mononuclear phagocyte system , macrophage , biology , phagocyte , spleen , immunology , autoimmune disease , bone marrow , peripheral blood mononuclear cell , systemic lupus erythematosus , monocyte , disease , phagocytosis , pathology , medicine , antibody , biochemistry , in vitro
During the course of lupus‐like autoimmune disease male BXSB mice develop an increasing monocytosis in the peripheral blood. As we demonstrated previously, this monocytosis is parallelled by an expansion of a strain‐specific high number of macrophage precursor cells (CFU‐M) in the bone marrow of male mice. To test the hypothesis that the expanded mononuclear phagocyte system (MPS) may promote autoimmune disease in these mice the organ‐associated macrophage system was examined. Our latest data show that an unusual expansion of CFU‐M also appears in spleen and liver of male mice 2 weeks after birth. In addition to a morphological alteration of the organs during the course of the disease there is a change in number and distribution of organ‐resident macrophages. Considering these results the possible contribution of the expanded MPS in promoting autoimmune disease is discussed.