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The effect of granulocyte‐macrophage colony‐stimulating factor on myeloid cells and its clinical applications
Author(s) -
Hill Arnold D.K.,
Naama Hassan A.,
Calvano Steve E.,
Daly John M.
Publication year - 1995
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.58.6.634
Subject(s) - biology , granulocyte macrophage colony stimulating factor , myeloid cells , granulocyte macrophage colony stimulating factor receptor , macrophage , granulocyte , myeloid , immunology , colony stimulating factor , cancer research , microbiology and biotechnology , macrophage colony stimulating factor , cytokine , haematopoiesis , in vitro , biochemistry , stem cell
Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) is a naturally occurring growth factor produced by several cell types in response to a variety of stimuli. GM‐CSF has potent stimulatory effects on the growth and maturation of hematopoietic cells and has profound effects on mature circulating effector cells. Clinical applications of GM‐CSF include ameliorating chemotherapy‐induced neutropenia and enhancing hematopoietic recovery after bone marrow transplantation. This review evaluates the effect of GM‐CSF on myeloid cells and its clinical applications.