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Proteases and protease receptors in modulation of leukocyte effector functions
Author(s) -
Altieri Dario C.
Publication year - 1995
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.58.2.120
Subject(s) - proteases , biology , microbiology and biotechnology , effector , signal transduction , immune system , protease , protease activated receptor , receptor , monocyte , immunology , enzyme , biochemistry , thrombin , platelet
Cellular immune responses depend on regulated pathways of intracellular signal transduction and leukocyte activation. Although these mechanisms are coordinated by a variety of leukocyte‐restricted effector molecules, recent observations have uncovered a novel role of proteases in transducing outside‐in signals of leukocyte activation. Through regulated, receptor‐mediated recognitions, coagulation and fibrinolytic enzymes or effector cell granular proteases influence monocyte motility and chemotaxis, modulate pleiotropic cytokine responses, contribute to mononuclear cell proliferation, or induce target cell apoptosis. Overall, these mechanisms define a novel interface between general inflammatory reactions, invariably characterized by activation of blood protease cascades, and specialized aspects of cellular immune functions. J. Leukoc. Biol. 58: 120–127; 1995.