Premium
Slow Ca 2+ waves in large myeloid cells as a result of a diffusible cytosolic factor
Author(s) -
Roberts G. M.,
Davies E.V.,
Hallett M.B.
Publication year - 1995
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.57.6.837
Subject(s) - endoplasmic reticulum , cytosol , biology , microbiology and biotechnology , myeloid cells , myeloid , biophysics , immunology , biochemistry , enzyme
In the work reported here evidence is provided that shows the slow wave of Ca 2+ large neonatal myeloid cells provoked by formyl‐Met‐Leu‐Phe was generated by spatially delayed Ca 2+ influx. Evidence is provided that the delay in Ca 2+ influx was the result of diffusion of a factor from the Ca 2+ storage site, which is responsible for Ca 2+ channel opening. The location of the Ca 2+ release site was correlated with a region near the nucleus, probably a specialized region of endoplasmic reticulum. It is proposed that similar mechanisms of Ca 2+ signaling occur in mature myeloid cells, such as neutrophils, but on a shorter time scale as a consequence of their smaller size. J. Leukoc. Biol. 57: 837–841; 1995.