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Interleukin‐3, granulocyte‐macrophage colony‐stimulating factor, and interleukin‐5 transduce signals through two forms of STAT5
Author(s) -
Mui Alice L.F.,
Wakao Hiroshi,
Harada Nobuyuki,
O'Farrell AnneMarie,
Miyajima Atsushi
Publication year - 1995
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.57.5.799
Subject(s) - biology , stat5 , granulocyte macrophage colony stimulating factor , interleukin 3 , immunology , colony stimulating factor , granulocyte , granulocyte macrophage colony stimulating factor receptor , interleukin , macrophage , microbiology and biotechnology , cytokine , macrophage colony stimulating factor , signal transduction , haematopoiesis , immune system , t cell , biochemistry , il 2 receptor , stem cell , in vitro
Recently, JAK2 kinase was found to be one of the tyrosine kinases activated by interleukin‐3 (IL‐3) in target cells. JAK2 belongs to a family of kinases that act upstream of transcription factors called STATs. STATs exist in the cytoplasm as latent, transcriptionally inactive forms until, in response to extracellular signals, they become phosphorylated on tyrosine residues, translocate to the nucleus, and bind to specific DNA elements. Because IL‐3 activates JAK2, we searched for the STAT(s) that might transduce IL‐3 signals. Several lines of evidence suggest that IL‐3 uses the murine homologue of STAT5, a factor originally purified from sheep. Unexpectedly, during isolation of the murine homologue, we found two highly related molecules that we have designated STAT5A and STAT5B. J. Leukoc. Biol. 57: 799–803; 1995.