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Receptors, signal transduction, and spectrum of action of monocyte chemotactic protein‐1 and related chemokines
Author(s) -
Sozzani Silvano,
Locati Massimo,
Zhou Dan,
Rieppi Monica,
Luini Walter,
Lamorte Giuseppe,
Bianchi Giancario,
Polentarutti Nadia,
Allavena Paola,
Mantovani Alberto
Publication year - 1995
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.57.5.788
Subject(s) - chemokine , chemotaxis , signal transduction , biology , monocyte , microbiology and biotechnology , receptor , immunology , chemokine receptor , inflammation , biochemistry
Chemokines are a bipartite family of chemotactic proteins that bear the structural hallmark of four cysteine residues, the first two of which are in tandem. The spectrum of action of C‐C chemokines, monocyte chemotactic protein‐1 (MCP‐1), MCP‐2, and MCP‐3, in particular, encompasses, in addition to monocytes, other leukocyte populations. Evidence is presented that MCP‐1, MCP‐2, and MCP‐3 are active on natural killer cells. Available information on receptor usage by MCP‐1 and related chemokines and signal transduction pathways is reviewed. A better understanding of signaling mechanisms will provide a new basis for therapeutic strategies. J. Leukoc. Biol. 57: 788–794; 1995.