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NFATp, a cyclosporin‐sensitive transcription factor implicated in cytokine gene induction
Author(s) -
Rao Anjana
Publication year - 1995
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.57.4.536
Subject(s) - biology , transcription factor , calcineurin , gene , transcription (linguistics) , tcf4 , response element , cytokine , taf2 , e box , microbiology and biotechnology , genetics , gene expression , promoter , medicine , linguistics , philosophy , transplantation , enhancer
The transcription factor NFATp (nuclear factor of activated T cells, preexisting) is likely to regulate the cyclosporin‐sensitive transcription of cytokine genes and other activation‐associated genes during the immune response. NFATp is the first identified member of a new family of transcription factors, whose DNA binding do mains show a weak sequence similarity to those of the Rel (NF‐ x B) family of proteins. NFATp is expressed in several types of immune cells as a cytosolic protein that translo cates to the nucleus following activation. The nuclear translocation is regulated by calcium and calcineurin and inhibited by cyclosporin A and FK506. In the nucleus, NFATp cooperates with Fos‐Jun dimers and possibly with other transcription factors at composite elements in the regulatory regions of cytokine genes. The potential roles of NFATp and a related family member, NFATc, in cytokine gene transcription are discussed. J. Leukoc. Biol. 57: 536–542; 1995.