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A direct signaling pathway through tyrosine kinase activation of SH2 domain‐containing transcription factors
Author(s) -
Fu XinYuan
Publication year - 1995
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.57.4.529
Subject(s) - transcription factor , signal transduction , proto oncogene tyrosine protein kinase src , biology , microbiology and biotechnology , stat protein , jak stat signaling pathway , tyrosine kinase , sh2 domain , activator (genetics) , receptor tyrosine kinase , cancer research , gene , stat3 , genetics
Studies on the mechanism of interferoninduced gene expression revealed a direct signaling path way from ccl1 surface receptors to transcription factors. In this pathway, signal transduction is mediated by a new class of transcription factor STAT (signal transducer and activator of transcription). We have shown that STAT fac tors contain Src homology region 2 and 3 domains and arc phosporylated and activated in the cytoplasm by rcccptor associated tyrosine kinases. The activated tran scription factors then translocate to the nucleus, joined by a nuclcar DNA binding factor, to form an active tran scriptional complex. Recent studies have shown that this direct signaling pathway is the key to control of gene ex pression induced by many cytokines and growth factors. J. Leukoc. BioL 57: 529–535; 1995.