Premium
Review of the macrophage disappearance reaction
Author(s) -
Barth Malcolm W.,
Hendrzak Jill A.,
Melnicoff Meryle J.,
Morahan Page S.
Publication year - 1995
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.57.3.361
Subject(s) - macrophage , immune system , immunology , biology , hypersensitivity reaction , immune reaction , inflammation , in vitro , biochemistry
Macrophages (M φ s) undergo a physiological response known as the macrophage disappearance reaction (MDR) in response to certain stimuli in the peritoneal compartment. The types of stimuli that can cause the MDR, the relationship of the MDR to the host immunological response, and the possible role of the MDR in M φ activation are reviewed. The data indicate that the MDR occurs in response to both acute nonspecific inflammatory and specific immune delayed hypersensitivity processes and that the MDR may play an important role in M φ activation. J. Leukoc. Biol . 57: 361–367; 1995.