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Interleukin‐9 and its receptor: involvement in mast cell differentiation and T cell oncogenesis
Author(s) -
Renauld JeanChristophe,
Kermouni Abdenaim,
Vink Anne,
Louahed Jamila,
Van Snick Jacques
Publication year - 1995
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.57.3.353
Subject(s) - biology , autocrine signalling , cytokine , mast cell , interleukin 3 , microbiology and biotechnology , haematopoiesis , receptor , progenitor cell , signal transduction , cell growth , t cell , immunology , cancer research , stem cell , il 2 receptor , immune system , biochemistry , genetics
Intcrleukin‐9 (IL‐9) is a multifunctional cytokine produced by activated TH2 clones in vitro and during TH2‐like T cell responses in vivo. The IL‐9 receptor is a member of the hemopoietin receptor superfamily and interacts with the γ chain of the IL‐2 receptor for signal transduction. Various observations indicate that IL‐9 is actively involved in mast cell responses by inducing the proliferation and differentiation of these cells. The role of IL‐9 in T cell responses is less clear. Although freshly isolated normal T cells do not respond to IL‐9, this cytokine induces the proliferation of murine T cell lymphomas in vitro and in vivo overexpression of IL‐9 results in the development of thymic lymphomas. In the human, the existence of an IL‐9‐mediated autocrine loop has been suggested for some malignancies such as Hodgkin's disease. Other potential biological targets for IL‐9 include B lymphocytes, hematopoietic progenitors, and immature neuronal cell lines. J. Leukoc. Biol . 57: 353–360; 1995.