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Influence of age on the production of Fos and Jun by influenza virus‐exposed T cells
Author(s) -
Salkind Alan R.
Publication year - 1994
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.56.6.817
Subject(s) - biology , virology , virus , influenza a virus
This study investigated age‐related T cell responses after in vitro exposure to influenza A virus. Mononuclear leukocytes from young or elderly persons were sham‐exposed or exposed to influenza virus for 1, 24, and 72 h. Immunofluorescent staining and flow cytometric analysis were then used to detect T cells producing the transcriptional regulating proteins Fos and Jun. Fewer virus‐exposed cells from elderly donors stained for Fos and Jun at each data point compared with cells from young donors. Flow cytometric analysis also showed that at 72 h of virus exposure fewer T cells from the elderly produced interferon‐gamma (IFN‐ γ ), suggesting a link between the magnitude of the Fos and Jun and IFN‐ γ responses. Thus, failure of virus‐exposed T cells to produce Fos and Jun could contribute to the increase in illness due to influenza virus in the elderly. J. Leukoc. Biol. 56: 817–820; 1994.