Premium
Effects of fatty acids on proliferation and activation of human synovial compartment lymphocytes
Author(s) -
DeMarco Deborah M.,
Santoli Daniela,
Zurier Robert B.
Publication year - 1994
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.56.5.612
Subject(s) - compartment (ship) , eicosanoid , rheumatoid arthritis , eicosapentaenoic acid , biology , synovial fluid , arachidonic acid , synovial membrane , fatty acid , cell growth , immunology , biochemistry , pharmacology , polyunsaturated fatty acid , medicine , pathology , enzyme , oceanography , osteoarthritis , alternative medicine , geology
Abstract The object of this study was to determine the effects of eicosanoid precursor fatty acids on activation and proliferation of T lymphocytes from synovial fluid and synovial tissue of rheumatoid arthritis patients. Proliferation was determined by direct cell counts; phenotypic characterization of surface molecules was by cytofluorometric analysis. Dihomogammalinolenic acid, arachidonic acid, and eicosapentaenoic acid suppressed proliferation of interleukin‐2‐dependent lymphocytes by as much as 80%; cell viability was not altered by fatty acids. Administration of particular fatty acids may prove to be a useful therapeutic intervention in rheumatoid arthritis patients because of their ability to suppress activation and proliferation of synovial compartment T lymphocytes. J. Leukoc. Biol. 56: 612–615; 1994.