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Establishment of the role of IL‐6 and TNF receptor 1 using gene knockout mice
Author(s) -
Bluethmann Horst,
Rothe Joachim,
Schultze Nathalie,
Tkachuk Maria,
Koebel Pascale
Publication year - 1994
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.56.5.565
Subject(s) - biology , knockout mouse , gene knockout , gene , receptor , tumor necrosis factor alpha , microbiology and biotechnology , genetics , immunology
Cytokines are known to be key players in host response to infection, immunological disorders, and tissue injury in the attempt of an organism to overcome the insult and restore homeostasis. Another important aspect of cytokines, however, is their normal physiological role during development in the unchallenged organism. The most elegant way to analyze both of these functions is to introduce targeted mutations in embryonic stem cells in order to create new mouse strains deficient for a given cytokine and identify the functions that are consequently impaired or lost, This review summarizes the mutant phenotypes of mice carrying a null mutation in the cytokine IL‐6 gene or the tumor necrosis factor receptor 1 ( Tnfr1 ) gene. Results for interferon– and interferon‐ γ receptor‐deficient mice are included for comparison. J. Leukoc. Biol. 56: 565–570; 1994.