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Macrophages/microglia and the pathophysiology of CNS injuries in AIDS
Author(s) -
Gendelman Howard E.,
Tardieu Marc
Publication year - 1994
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.56.3.387
Subject(s) - microglia , biology , central nervous system , astrocyte , neuroscience , neurotoxicity , disease , pathophysiology , human immunodeficiency virus (hiv) , immunology , pathology , medicine , inflammation , toxicity , endocrinology
How HIV‐1 penetrates the central nervous system (CNS) and induces neurological disease remains poorly understood. Clinical and pathological consequences of HIV‐1 associated CNS infections are the subjects of a relatively new field comprising a spectrum of many brain diseases including those that are HIV‐1 associated or secondary to bacterial, fungal, protozoal, or tumor infiltration of brain. The molecular and biological approaches used to study HIV‐1‐mediated brain disease are interdisciplinary. A wide variety of expertise and cooperative research efforts is required between molecular virologists, cellular immunologists, and neurobiologists. Indeed, specialists studying microglial maturation, astrocyte function, neurotoxicity, HIV‐1 neurovirulence, and apoptosis all play pivotal roles in examining facets of this disease complex.