13‐HODE inhibits the intracellular calcium increase of activated human polymorphonuclear cells | Zendy

Velde Marco J. | Zendy; Engels Ferdi | Zendy; Henricks Paul A. J. | Zendy; Nijkamp Frans P. | Zendy

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13‐HODE inhibits the intracellular calcium increase of activated human polymorphonuclear cells

Author(s) -

Velde Marco J.,

Engels Ferdi,

Henricks Paul A. J.,

Nijkamp Frans P.

Publication year - 1994

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1002/jlb.56.2.200

Subject(s) - leukotriene b4 , calcium , intracellular , metabolite , calcium in biology , linoleic acid , biology , leukotriene , biochemistry , microbiology and biotechnology , chemistry , immunology , inflammation , fatty acid , organic chemistry , asthma

We studied the effect of the linoleic acid metabolite 13‐hydroxyoctadecadienoic acid (13‐HODE) on the increase of the intracellular calcium concentration, [Ca 2+ ]i, induced by platelet‐activating factor (PAF), leukotriene B 4 (LTB 4 ), and formyl‐Met‐Leu‐Phe (fMLP) in human polymorphonuclear leukocytes (PMNs). 13‐HODE by itself did not change the [Ca 2+ ]i of PMNs. However, when PMNs were preincubated with 13‐HODE and subsequently stimulated with PAF, LTB 4 , or fMLP, an inhibition of the increase of the [Ca 2+ ]i was observed. The PAF‐induced calcium response was concentration‐dependently inhibited between 0.1 and 5 μ M 13‐HODE. These results suggest that 13‐HODE can affect the increase of the [Ca 2+ ]i and hence can modulate activation of PMNs. J. Leukoc. Biol . 56: 200–202; 1994.

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